Avanafil
Avanafil, often recognized under the brand name Spedra, is an oral medication primarily used to treat erectile dysfunction (ED) in men. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. Think of it as a key that helps unlock improved blood flow – specifically to the penis – enabling a firmer and more sustained erection when sexually stimulated. While a specific manufacturer isn’t always highlighted, several pharmaceutical companies produce generic versions once patent protections expire.
This medication doesn’t magically cause an erection; rather, it enhances the body’s natural response to sexual stimulation. It works by relaxing the muscles in the penis and increasing blood flow, making it easier to achieve and maintain an erection sufficient for satisfactory sexual activity. It’s a relatively modern treatment option, offering a faster onset of action compared to some older ED medications.
Avanafil is not a cure for erectile dysfunction; it’s a treatment that manages the symptoms. It addresses the physical mechanism behind many cases of ED, but doesn’t tackle underlying psychological factors which may also contribute. It’s important to remember that lifestyle changes – like maintaining a healthy weight, regular exercise, and managing stress – can often complement medication for optimal results.
Forms and Dosages
Avanafil is currently available solely in tablet form, offering convenience and ease of use. The standard dosages include 50mg, 100mg, and 200mg strengths. The appropriate dosage will be determined by your doctor based on your individual health status, the severity of your ED, and any other medications you may be taking. It’s crucial to follow their instructions precisely.
These tablets are typically film-coated for easier swallowing. They should be swallowed whole with water; do not crush or chew them as this can affect how quickly the medication is absorbed into your system. Unlike some medications, Avanafil tablets are not scored, meaning they shouldn’t be split to achieve a lower dose – always use the prescribed strength.
The unique aspect of Avanafil lies in its rapid onset of action. It’s designed to be taken approximately 15-30 minutes before anticipated sexual activity, offering flexibility for spontaneous encounters. This contrasts with other PDE5 inhibitors that often require an hour or more to become effective.
Who Can Take It?
Avanafil is specifically indicated for use in adult men experiencing erectile dysfunction. There’s currently no approved use of Avanafil for women or children. Generally, it’s considered safe for most men within a broad age range, but extra caution is advised for those over 65 due to potential increased sensitivity to the medication and co-existing health conditions.
Individuals with certain pre-existing medical conditions require careful evaluation before starting Avanafil. These include cardiovascular disease (heart problems), liver or kidney issues, uncontrolled high blood pressure, and a history of stroke or heart attack. It’s vital to have an open discussion with your doctor about any existing health concerns.
Pregnant women should absolutely avoid taking Avanafil, as its effects on fetal development are unknown. Similarly, breastfeeding mothers should not use this medication due to potential transfer into breast milk. It’s always best to err on the side of caution when it comes to medications and reproductive health.
How to Take Avanafil
Avanafil is typically taken on demand, meaning you take a tablet only when you anticipate sexual activity, rather than daily. It can be taken with or without food; however, taking it on an empty stomach may lead to faster absorption and therefore quicker onset of action. Avoid consuming high-fat meals around the time you take Avanafil as this could delay its effects.
The recommended frequency is no more than once per day. Do not exceed the prescribed dosage under any circumstances. If you miss a dose, simply take it when you remember – but only if your planned sexual activity is still within the timeframe of effectiveness (up to 36 hours). Do not double the dose to compensate for a missed one.
It’s important to allow sufficient time for the medication to work before engaging in sexual activity. As mentioned, Avanafil typically begins working within 15-30 minutes, but individual responses can vary. If you experience no improvement after this timeframe, do not take another tablet; consult your doctor instead.
How It Works
At its core, Avanafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). This enzyme is responsible for breaking down a substance called cyclic guanosine monophosphate (cGMP) in the penis. cGMP plays a crucial role in relaxing smooth muscle cells and allowing increased blood flow into the erectile tissues.
By blocking PDE5, Avanafil prevents the breakdown of cGMP, leading to higher levels of this substance. This results in sustained relaxation of the penile muscles, facilitating an erection when sexual stimulation occurs. Think of it like turning up the volume on a signal that tells your body to increase blood flow where it’s needed most.
It’s important to reiterate: Avanafil doesn’t create an erection out of thin air. Sexual stimulation is still required to trigger the release of nitric oxide, which initiates the cGMP pathway. The medication simply amplifies this natural process, making it easier to achieve and maintain an erection.
Contraindications
Certain medical conditions and medications make Avanafil unsuitable for use. Individuals taking nitrates – often prescribed for chest pain (angina) – should never take Avanafil. Combining these drugs can cause a dangerous drop in blood pressure, potentially leading to serious cardiovascular complications. This is a non-negotiable contraindication.
Similarly, Avanafil should not be used by anyone taking guanylate cyclase stimulators like riociguat, as this combination also carries a significant risk of hypotension. If you have recently taken ‘poppers’ (amyl nitrite or butyl nitrate), recreational drugs often used to relax muscles, avoid using Avanafil for at least 24-48 hours due to the potential for dangerous interactions.
Individuals with severe liver or kidney disease should also avoid Avanafil, as these conditions can affect how the drug is metabolized and eliminated from the body. A history of stroke, heart attack, or uncontrolled high blood pressure are further reasons to discuss alternative treatment options with your doctor.
Interactions
Avanafil can interact with a variety of other medications, potentially altering its effectiveness or increasing the risk of side effects. It’s crucial to inform your doctor about all drugs you’re taking, including prescription medications, over-the-counter remedies, herbal supplements, and vitamins.
Certain antifungal medications (like ketoconazole and itraconazole) can increase Avanafil levels in the bloodstream, potentially leading to more pronounced side effects. Similarly, some antibiotics (such as clarithromycin and erythromycin) may have a similar effect.
Avoid consuming excessive amounts of alcohol while taking Avanafil, as this can worsen certain side effects like dizziness and headache. Grapefruit juice is also known to interact with several medications, including PDE5 inhibitors; it’s best to avoid it altogether when using Avanafil.
Side Effects
Like all medications, Avanafil can cause side effects, although they are generally mild and temporary. Common side effects include headache, flushing (redness of the face), nasal congestion, indigestion, and back pain. These typically resolve on their own within a few hours.
Less common side effects may include dizziness, muscle aches, visual disturbances (such as blurred vision or changes in color perception), and decreased blood pressure. If you experience any of these symptoms, contact your doctor for advice.
Serious side effects are rare but require immediate medical attention. These include priapism (a prolonged erection lasting more than four hours), sudden loss of vision or hearing, and signs of an allergic reaction (such as rash, hives, swelling, or difficulty breathing).
Overdose Risks
An Avanafil overdose is unlikely to be life-threatening but can cause unpleasant symptoms. Symptoms may include severe headache, dizziness, flushing, visual disturbances, and low blood pressure. If you suspect an overdose, seek immediate medical attention – call emergency services or go to the nearest hospital.
It’s important not to panic, but prompt action is crucial. Medical professionals will assess your condition and provide appropriate treatment, which may include supportive care to manage symptoms and monitor vital signs. Do not attempt to induce vomiting unless specifically instructed by a healthcare provider.
Price and Availability
The cost of Avanafil varies depending on the dosage strength, quantity purchased, and whether you choose branded or generic versions. Generally, generic Avanafil is significantly more affordable than the brand-name Spedra. Prices can range from £2 to £10 per tablet, depending on these factors.
Avanafil is available for purchase through registered pharmacies both online and in brick-and-mortar stores. Online pharmacies often offer competitive pricing and convenient home delivery services. However, it’s essential to choose a reputable and licensed pharmacy to ensure you’re receiving genuine medication.
Buying Drugs Without Prescription Info (for United Kingdom)
In the United Kingdom, Avanafil is classified as a prescription-only medicine (POM). This means you cannot legally purchase it over the counter without a valid prescription from a qualified healthcare professional. However, online pharmacies like Medicade offer convenient access to Avanafil through an online consultation process.
This involves completing a medical questionnaire and potentially having a virtual appointment with a doctor who will assess your suitability for the medication. If approved, they will issue a prescription that is then dispensed by the pharmacy. It’s crucial to ensure any online pharmacy you use is registered with the General Pharmaceutical Council (GPhC).
| City | Estimated Delivery Time |
|---|---|
| London | 1-2 working days |
| Manchester | 2-3 working days |
| Birmingham | 2-3 working days |
| Glasgow | 3-4 working days |
| Cardiff | 2-3 working days |
Alternatives
Several other medications are available for treating erectile dysfunction, offering alternatives to Avanafil. These include Sildenafil (Viagra), Tadalafil (Cialis), and Vardenafil (Levitra). Each drug has its own unique characteristics in terms of onset of action, duration of effect, and potential side effects.
Lifestyle changes can also serve as natural alternatives or complementary therapies. Maintaining a healthy weight, exercising regularly, managing stress, and quitting smoking can all improve erectile function. Some herbal remedies are marketed for ED, but their effectiveness is often unproven and they may interact with other medications.
Precautions
Before starting Avanafil, inform your doctor about any existing medical conditions, allergies, and medications you’re taking. Avoid consuming excessive alcohol or grapefruit juice while on this medication. Store Avanafil in a cool, dry place away from direct sunlight and moisture. Keep it out of reach of children.
Be aware of the potential side effects and seek immediate medical attention if you experience any serious symptoms. Regular check-ups with your doctor are essential to monitor your response to the medication and ensure its continued safety and effectiveness.
FAQ Section
Q: How long does Avanafil last? A: Avanafil typically lasts for up to 36 hours, offering a longer window of opportunity compared to some other ED medications.
Q: Can I take Avanafil with other medications? A: It’s crucial to inform your doctor about all medications you’re taking before starting Avanafil, as interactions can occur.
Q: What should I do if Avanafil doesn’t work for me? A: Do not take another tablet. Consult your doctor to discuss alternative treatment options.
Reviewed by a Medical Professional
Reviewed by a medical professional Isabel D White.
