Fluoxetine
Fluoxetine, commonly known as Prozac (a brand name previously held by Eli Lilly and now generic), is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It’s a medication prescribed to treat a range of mental health conditions, including major depressive disorder, obsessive-compulsive disorder (OCD), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder (PMDD). Think of it as gently nudging your brain’s natural chemical balance back into harmony.
Fluoxetine works by increasing the levels of a neurotransmitter called serotonin in the brain. Serotonin plays a crucial role in regulating mood, sleep, appetite, and other important functions. When someone experiences depression or anxiety, serotonin levels are often low. Fluoxetine essentially prevents the reabsorption of serotonin, making more of it available to transmit messages between nerve cells.
It’s important to remember that fluoxetine isn’t a quick fix; it typically takes several weeks to experience its full effects. It doesn’t ‘cure’ these conditions but manages symptoms effectively, allowing individuals to regain control and improve their quality of life. The medication is available in the UK through prescription only, ensuring appropriate medical supervision.
Available Forms & Dosages
Fluoxetine primarily comes in tablet form for oral administration. These tablets are typically film-coated for easier swallowing and come in various strengths: 20mg, 30mg, 40mg, and 60mg. The dosage is highly individualized, determined by your doctor based on the specific condition being treated, its severity, and your response to the medication.
Generally, treatment begins with a lower dose – often 20mg daily – which may be gradually increased over time if needed. Extended-release capsules are also available, offering a more sustained release of the medication throughout the day. These can be particularly helpful for individuals who struggle with remembering to take their medication multiple times a day.
Whether or not tablets can be split depends on whether they have a score line. If present, splitting is generally safe; however, it’s always best to confirm this with your pharmacist. It’s crucial not to crush or chew extended-release capsules as this will disrupt the controlled release mechanism and potentially lead to adverse effects.
Who Can Take Fluoxetine?
Fluoxetine can be prescribed for both men and women, typically adults aged 18 years and over. However, its use in children and adolescents (aged 8-18) is sometimes considered under strict medical supervision, primarily for the treatment of obsessive-compulsive disorder (OCD). The decision to prescribe fluoxetine to younger individuals requires careful consideration of potential risks and benefits.
Extra caution is advised when prescribing fluoxetine to elderly patients due to potential drug interactions and increased sensitivity to side effects. Individuals with liver or kidney problems may also require dosage adjustments. Pregnant or breastfeeding women should discuss the risks and benefits of fluoxetine with their doctor, as it can potentially affect the developing fetus or infant.
It’s vital to inform your healthcare provider about any pre-existing medical conditions, including heart disease, epilepsy, bipolar disorder, or a history of suicidal thoughts, before starting fluoxetine treatment. These factors may influence the suitability and safety of the medication.
How To Take Fluoxetine Correctly
Fluoxetine is usually taken once daily, either with or without food. Consistency is key; try to take it at the same time each day to maintain a stable level of medication in your system. You can take fluoxetine with water, juice, or milk – whatever makes it easiest for you to remember.
If you miss a dose, take it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Never double up on doses to make up for a missed one, as this can increase the risk of side effects.
The duration of treatment varies depending on the condition being treated and individual response. It’s crucial to complete the full course of treatment, even if you start feeling better, unless your doctor advises otherwise. Abruptly stopping fluoxetine can lead to withdrawal symptoms, such as dizziness, nausea, anxiety, and sleep disturbances.
How Fluoxetine Works: A Simplified Explanation
Imagine your brain is a bustling city with messages constantly being sent between buildings (nerve cells). Serotonin is one of the key messengers responsible for regulating mood and emotions. In individuals experiencing depression or anxiety, this messaging system can become disrupted, leading to low serotonin levels.
Fluoxetine acts like a traffic controller, preventing the reabsorption of serotonin back into the sending nerve cells. This allows more serotonin to remain available in the spaces between nerve cells (synapses), enhancing communication and improving mood regulation. It doesn’t create serotonin; it simply makes better use of what’s already there.
This process isn’t instantaneous. It takes time for the brain to adjust to increased serotonin levels, which is why it typically takes several weeks to experience noticeable improvements in symptoms. Fluoxetine helps restore balance and allows the brain to function more effectively.
Contraindications: When Not To Use Fluoxetine
Fluoxetine isn’t suitable for everyone. Individuals with a known allergy to fluoxetine or any other SSRI antidepressant should avoid taking it. It’s also contraindicated in individuals taking monoamine oxidase inhibitors (MAOIs), either currently or within the past two weeks, as this combination can lead to a potentially life-threatening condition called serotonin syndrome.
People with certain medical conditions, such as severe liver disease, uncontrolled epilepsy, or a history of mania, should not take fluoxetine without careful consideration and monitoring by their doctor. Similarly, individuals taking thioridazine (an antipsychotic medication) should avoid fluoxetine due to the risk of heart rhythm abnormalities.
Drug Interactions: What To Be Aware Of
Fluoxetine can interact with a variety of other medications, potentially increasing or decreasing their effects. It’s crucial to inform your doctor about all medications you are taking, including prescription drugs, over-the-counter remedies, herbal supplements, and vitamins.
Combining fluoxetine with blood thinners (such as warfarin) may increase the risk of bleeding. Nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen or naproxen, can also interact with fluoxetine, potentially increasing the risk of stomach ulcers. Avoid consuming alcohol while taking fluoxetine, as it can worsen side effects and reduce the medication’s effectiveness.
Certain herbal supplements, such as St. John’s Wort, can also interact with fluoxetine and should be avoided. Always consult your doctor or pharmacist before starting any new medications or supplements while taking fluoxetine.
Potential Side Effects: What To Expect
Like all medications, fluoxetine can cause side effects. Common side effects are generally mild and temporary, including nausea, headache, insomnia, drowsiness, anxiety, and decreased libido. These typically subside within a few weeks as your body adjusts to the medication.
Less common side effects may include dry mouth, sweating, tremors, dizziness, and changes in appetite or weight. More serious side effects are rare but require immediate medical attention. These include suicidal thoughts or behaviors (especially in young adults), serotonin syndrome (characterized by confusion, agitation, muscle stiffness, and rapid heartbeat), abnormal bleeding, seizures, and allergic reactions.
If you experience any concerning side effects, contact your doctor immediately. Do not stop taking fluoxetine abruptly without consulting your healthcare provider.
Overdose Risks & What To Do
An overdose of fluoxetine can be dangerous and potentially life-threatening. Symptoms may include confusion, agitation, tremors, seizures, irregular heartbeat, nausea, vomiting, and coma. The amount considered an overdose varies depending on individual factors such as weight, age, and overall health.
If you suspect someone has overdosed on fluoxetine, seek immediate medical attention. Call emergency services (999 in the UK) or take the person to the nearest hospital. Provide as much information as possible about the amount of medication taken and any other substances consumed. Do not induce vomiting unless instructed by a healthcare professional.
Price & Availability
The price of fluoxetine varies depending on the dosage, quantity, and whether you purchase it from a retail pharmacy or online. Generic fluoxetine is generally more affordable than brand-name versions. As of late 2025, a typical prescription for 30 tablets of 20mg fluoxetine can range from £15 to £30 in the UK.
Fluoxetine is available through most pharmacies and online retailers like https://medicade.co.uk/. Online pharmacies often offer competitive prices and convenient home delivery services. However, it’s essential to ensure that any online pharmacy you use is registered with the General Pharmaceutical Council (GPhC) to guarantee its legitimacy and safety.
Buying Drugs Without a Prescription in the UK
In the United Kingdom, fluoxetine is classified as a prescription-only medicine (POM). This means it cannot be legally purchased over the counter without a valid prescription from a qualified healthcare professional. Attempting to obtain fluoxetine without a prescription is illegal and potentially dangerous.
However, online pharmacies like https://medicade.co.uk/ offer convenient access to prescriptions through online consultations with registered doctors or pharmacists. This allows you to receive a legitimate prescription and have your medication delivered directly to your door.
| City | Estimated Delivery Time |
|---|---|
| London | Next Day |
| Manchester | Next Day |
| Birmingham | Next Day |
| Glasgow | 2-3 Working Days |
| Cardiff | 2-3 Working Days |
Alternatives To Fluoxetine
While fluoxetine is an effective treatment for many, it’s not the only option. Other SSRI antidepressants, such as sertraline, paroxetine, and citalopram, work similarly and may be suitable alternatives. Serotonin-norepinephrine reuptake inhibitors (SNRIs), like venlafaxine and duloxetine, are another class of antidepressants that can be effective for some individuals.
For those seeking non-pharmacological approaches, cognitive behavioral therapy (CBT) is a highly effective form of psychotherapy that helps individuals identify and change negative thought patterns and behaviors. Lifestyle modifications, such as regular exercise, a healthy diet, and sufficient sleep, can also play a significant role in managing depression and anxiety.
Important Precautions & Warnings
Before starting fluoxetine, inform your doctor about any allergies you have, especially to medications. Be sure to discuss any pre-existing medical conditions, including heart problems, liver or kidney disease, epilepsy, bipolar disorder, or a history of suicidal thoughts. Do not drink alcohol while taking fluoxetine, as it can worsen side effects and reduce the medication’s effectiveness.
Store fluoxetine in a cool, dry place away from direct sunlight and moisture. Keep it out of reach of children and pets. If you are planning to undergo surgery or any medical procedure, inform your doctor that you are taking fluoxetine.
Frequently Asked Questions (FAQ)
- How long does it take for Fluoxetine to work? It typically takes 4-6 weeks to experience the full benefits of fluoxetine.
- Can I stop taking Fluoxetine suddenly? No, abruptly stopping fluoxetine can cause withdrawal symptoms. Always taper off gradually under your doctor’s supervision.
- Will Fluoxetine affect my sex life? Sexual side effects are possible with fluoxetine, such as decreased libido or difficulty achieving orgasm. Discuss this with your doctor if it concerns you.
- Is Fluoxetine addictive? Fluoxetine is not considered addictive in the traditional sense, but stopping it abruptly can cause withdrawal symptoms.
Reviewed by a Medical Professional
Reviewed by a medical professional Isabel D White.
